OFF-State-Specific Inhibition of the Proprotein Convertase Furin
Author:
Affiliation:
1. Department of Biosciences, University of Salzburg, Hellbrunnerstraße 34, A-5020 Salzburg, Austria
2. Department of Pharmaceutical Chemistry, Philipps University Marburg, Marbacher Weg 6, D-35032 Marburg, Germany
Funder
Bundesministerium f??r Bildung und Forschung
Austrian Science Fund
LOEWE Center DRUID
Publisher
American Chemical Society (ACS)
Subject
Molecular Medicine,General Medicine,Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acschembio.1c00411
Reference44 articles.
1. Proprotein Convertases in Health and Disease
2. The Proteolytic Regulation of Virus Cell Entry by Furin and Other Proprotein Convertases
3. TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cells
4. The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade
5. A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells
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