Discovery of Benzodiazepine-Based Inhibitors of the E2 Enzyme UBCH10 from a Cell-Based p21 Degradation Screen-Reference-Cited by-同舟云学术

Discovery of Benzodiazepine-Based Inhibitors of the E2 Enzyme UBCH10 from a Cell-Based p21 Degradation Screen

Published:2023-04-25 Issue:5 Volume:18 Page:1039-1046
ISSN:1554-8929
Container-title:ACS Chemical Biology
language:en
Short-container-title:ACS Chem. Biol.

Author:

Pelletier Benoit¹,Duhamel Stéphanie¹,Tambutet Guillaume¹,Jarvis Scott¹,Cléroux Patrick¹,David Maud¹,Tanguay Pierre-Luc¹,Voisin Laure¹,James Clint¹^ORCID,Lavoie Rico¹,Gareau Yves¹,Flynn-Robitaille Joël¹,Lorca Thierry²,Ruel Réjean¹,Marinier Anne¹³⁴,Meloche Sylvain¹⁴⁵^ORCID

Affiliation:

1. Institute for Research in Immunology and Cancer, Montreal, Quebec H3C 3J7, Canada

2. Université de Montpellier, Centre de Recherche en Biologie Cellulaire de Montpellier (CRBM), CNRS, UMR 5237, 34293 Montpellier Cedex 05, France

3. Department of Chemistry, Université de Montréal, Montreal, Quebec H3C 3J7, Canada

4. Department of Pharmacology and Physiology, Université de Montréal, Montreal, Quebec H3C 3J7, Canada

5. Molecular Biology Program, Faculty of Medicine, Université de Montréal, Montreal, Quebec H3C 3J7, Canada

Funder

Canadian Institutes of Health Research

Canadian Cancer Society Research Institute

Publisher

American Chemical Society (ACS)

Subject

Molecular Medicine,General Medicine,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acschembio.2c00909

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1. The Hallmarks of Cancer

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5. Ubiquitin signaling in cell cycle control and tumorigenesis

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