Spiroepoxytriazoles Are Fumagillin-like Irreversible Inhibitors of MetAP2 with Potent Cellular Activity-Reference-Cited by-同舟云学术

Spiroepoxytriazoles Are Fumagillin-like Irreversible Inhibitors of MetAP2 with Potent Cellular Activity

Published:2016-01-19 Issue:4 Volume:11 Page:1001-1011
ISSN:1554-8929
Container-title:ACS Chemical Biology
language:en
Short-container-title:ACS Chem. Biol.

Author:

Morgen Michael¹,Jöst Christian²,Malz Mona¹,Janowski Robert³,Niessing Dierk³⁴,Klein Christian D.²,Gunkel Nikolas¹,Miller Aubry K.¹

Affiliation:

1. Cancer Drug Development Group, German Cancer Research Center (DKFZ), Im Neunheimer Feld 280, D-69120 Heidelberg, Germany

2. Medicinal Chemistry, Institute of Pharmacy and Molecular Biotechnology (IPMB), Heidelberg University, Im Neuenheimer Feld 364, D-69120 Heidelberg, Germany

3. Institute of Structural Biology, Helmholtz Zentrum München, German Research Center for Environmental Health (HMGU), D-85764 Neuherberg, Germany

4. Biomedical Center of the Ludwig-Maximilians-Universität München, D-82152 Planegg-Martinsried, Germany

Funder

Helmholtz Association

Deutsche Krebshilfe

Deutsches Konsortium für Translationale Krebsforschung

Publisher

American Chemical Society (ACS)

Subject

Molecular Medicine,General Medicine,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acschembio.5b00755

Reference59 articles.

1. Drug Discovery and Natural Products: End of an Era or an Endless Frontier?

2. Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth

3. Chemical Modification of Fumagillin. I. 6-O-Acyl, 6-O-Sulfonyl, 6-O-Alkyl, and 6-O-(N-Substituted-carbamoyl)fumagillols.

4. Chemical Modification of Fumagillin. II. 6-Amino-6-deoxyfumagillol and Its Derivatives.

5. Chemical Modification of Fumagillin. III. Modification of the Spiro-epoxide.

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