Fragment Screening Reveals Starting Points for Rational Design of Galactokinase 1 Inhibitors to Treat Classic Galactosemia-Reference-Cited by-同舟云学术

Fragment Screening Reveals Starting Points for Rational Design of Galactokinase 1 Inhibitors to Treat Classic Galactosemia

Published:2021-03-16 Issue:4 Volume:16 Page:586-595
ISSN:1554-8929
Container-title:ACS Chemical Biology
language:en
Short-container-title:ACS Chem. Biol.

Author:

Mackinnon Sabrina R.¹^ORCID,Krojer Tobias¹,Foster William R.¹,Diaz-Saez Laura¹²,Tang Manshu³,Huber Kilian V. M.¹²^ORCID,von Delft Frank¹⁴^ORCID,Lai Kent³,Brennan Paul E.¹²^ORCID,Arruda Bezerra Gustavo¹,Yue Wyatt W.¹

Affiliation:

1. Structural Genomics Consortium, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, OX3 7DQ

2. Target Discovery Institute, University of Oxford, Oxford, United Kingdom, OX3 7FZ

3. Department of Pediatrics, University of Utah, Salt Lake City, Utah 84108-6500, United States

4. Diamond Light Source, Harwell Science and Innovation Campus, Didcot, Oxfordshire, United Kingdom, OX11 0DE

Funder

University of Oxford

Galactosemia Foundation

Wellcome Trust

Structural Genomics Consortium, University of Oxford

Publisher

American Chemical Society (ACS)

Subject

Molecular Medicine,General Medicine,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acschembio.0c00498

Reference47 articles.

1. Structure and Function of Enzymes of the Leloir Pathway for Galactose Metabolism

2. The structural and molecular biology of type I galactosemia: Enzymology of galactose 1-phosphate uridylyltransferase

3. Structural and molecular biology of type I galactosemia: Disease-associated mutations

4. The natural history of classic galactosemia: lessons from the GalNet registry

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