The Clinically Used Iron Chelator Deferasirox Is an Inhibitor of Epigenetic JumonjiC Domain-Containing Histone Demethylases-Reference-Cited by-同舟云学术

The Clinically Used Iron Chelator Deferasirox Is an Inhibitor of Epigenetic JumonjiC Domain-Containing Histone Demethylases

Published:2019-07-09 Issue:8 Volume:14 Page:1737-1750
ISSN:1554-8929
Container-title:ACS Chemical Biology
language:en
Short-container-title:ACS Chem. Biol.

Author:

Roatsch Martin¹^ORCID,Hoffmann Inga¹,Abboud Martine I.²^ORCID,Hancock Rebecca L.²,Tarhonskaya Hanna²,Hsu Kuo-Feng²,Wilkins Sarah E.²,Yeh Tzu-Lan²,Lippl Kerstin²,Serrer Kerstin³,Moneke Isabelle⁴,Ahrens Theresa D.⁵,Robaa Dina⁶,Wenzler Sandra¹,Barthes Nicolas P. F.¹^ORCID,Franz Henriette⁷,Sippl Wolfgang⁶^ORCID,Lassmann Silke⁵,Diederichs Sven⁴⁸,Schleicher Erik³,Schofield Christopher J.²^ORCID,Kawamura Akane²^ORCID,Schüle Roland⁷,Jung Manfred¹^ORCID

Affiliation:

1. Institute of Pharmaceutical Sciences, Albert-Ludwigs-Universität Freiburg, Albertstraße 25, 79104 Freiburg i.Br., Germany

2. Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, United Kingdom

3. Institute of Physical Chemistry, Albert-Ludwigs-Universität Freiburg, Albertstraße 21, 79104 Freiburg i.Br., Germany

4. Division of Cancer Research, Department of Thoracic Surgery, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, German Cancer Consortium (DKTK)-Partner Site Freiburg, Breisacher Straße 115, 79106 Freiburg i.Br., Germany

5. Institute for Surgical Pathology, Medical Center and Faculty of Medicine, University of Freiburg, Breisacher Straße 115a, 79106 Freiburg i.Br., Germany

6. Institute of Pharmacy, Martin-Luther-University Halle-Wittenberg, Wolfgang-Langenbeck-Straße 4, 06120 Halle (Saale), Germany

7. Central Clinical Research, Medical Center and Faculty of Medicine, University of Freiburg, Breisacher Straße 66, 79106 Freiburg i.Br., Germany

8. Division of RNA Biology & Cancer, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany

Funder

Tri-Service General Hospital, National Defense Medical Center, to Kuo-Feng Hsu

Publisher

American Chemical Society (ACS)

Subject

Molecular Medicine,General Medicine,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acschembio.9b00289

Reference71 articles.

1. Epigenetic protein families: a new frontier for drug discovery

2. Chromatin Modifications and Their Function

3. Histone demethylation by a family of JmjC domain-containing proteins

4. Reversal of Histone Lysine Trimethylation by the JMJD2 Family of Histone Demethylases

5. Studies on the catalytic domains of multiple JmjC oxygenases using peptide substrates

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