Enzymatic Synthesis of Diverse Heterocycles by a Noncanonical Nonribosomal Peptide Synthetase-Reference-Cited by-同舟云学术

Enzymatic Synthesis of Diverse Heterocycles by a Noncanonical Nonribosomal Peptide Synthetase

Published:2021-11-12 Issue:12 Volume:16 Page:2776-2786
ISSN:1554-8929
Container-title:ACS Chemical Biology
language:en
Short-container-title:ACS Chem. Biol.

Author:

Morgan Gina L.¹,Li Kelin²,Crawford Drake M.¹,Aubé Jeffrey¹²,Li Bo¹³^ORCID

Affiliation:

1. Department of Chemistry, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States

2. The Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States

3. Department of Microbiology and Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States

Funder

University of North Carolina at Chapel Hill

David and Lucile Packard Foundation

Rita Allen Foundation

Eunice Kennedy Shriver National Institute of Child Health and Human Development

Publisher

American Chemical Society (ACS)

Subject

Molecular Medicine,General Medicine,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acschembio.1c00623

Reference72 articles.

1. Glycopeptide antibiotic biosynthesis

2. The gene cluster for chloramphenicol biosynthesis in Streptomyces venezuelae ISP5230 includes novel shikimate pathway homologues and a monomodular non-ribosomal peptide synthetase gene The GenBank accession number for the sequence reported in this paper is AF262220.

3. Formation of an aminoacyl-S-enzyme intermediate is a key step in the biosynthesis of chloramphenicol

4. The Mechanism of ACV Synthetase

5. Enterobactin Biosynthesis in Escherichia coli: Isochorismate Lyase (EntB) Is a Bifunctional Enzyme That Is Phosphopantetheinylated by EntD and Then Acylated by EntE Using ATP and 2,3-Dihydroxybenzoate

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