A Fluorogenic Disaccharide Substrate for α-Mannosidases Enables High-Throughput Screening and Identification of an Inhibitor of the GH92 Virulence Factor from <i>Streptococcus pneumoniae</i>-Reference-Cited by-同舟云学术

A Fluorogenic Disaccharide Substrate for α-Mannosidases Enables High-Throughput Screening and Identification of an Inhibitor of the GH92 Virulence Factor from Streptococcus pneumoniae

Published:2023-08-02 Issue:8 Volume:18 Page:1730-1737
ISSN:1554-8929
Container-title:ACS Chemical Biology
language:en
Short-container-title:ACS Chem. Biol.

Author:

Bhosale Sandeep¹^ORCID,Deen Matthew C.¹,Proceviat Cameron¹,Hettle Andrew²,Winter Dana K.³,Brockerman Jacob⁴,Levene Marina¹^ORCID,Bennet Andrew J.¹^ORCID,Spino Claude³^ORCID,Boraston Alisdair B.²^ORCID,Vocadlo David J.¹⁴^ORCID

Affiliation:

1. Department of Chemistry, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada

2. Department of Biochemistry & Microbiology, University of Victoria, P.O. Box 3055 STN CSC, Victoria, British Columbia V8W 3P6, Canada

3. Département de Chimie, Université de Sherbrooke, Sherbrooke, Québec J1K 2R1, Canada

4. Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada

Funder

Canadian Institutes of Health Research

Canada Research Chairs

Natural Sciences and Engineering Research Council of Canada

Publisher

American Chemical Society (ACS)

Subject

Molecular Medicine,General Medicine,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acschembio.3c00053

Reference34 articles.

1. A refined palate: Bacterial consumption of host glycans in the gut

2. Mucosal glycan degradation of the host by the gut microbiota

3. Mucin glycan foraging in the human gut microbiome

4. Glycan‐metabolizing enzymes in microbe–host interactions: theStreptococcus pneumoniaeparadigm

5. How glycan metabolism shapes the human gut microbiota

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