SPR-Measured Dissociation Kinetics of PROTAC Ternary Complexes Influence Target Degradation Rate
Author:
Affiliation:
1. Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, James Black Centre, Dow Street, Dundee DD1 5EH, United Kingdom
2. Boehringer Ingelheim RCV GmbH & Co KG, 1221 Vienna, Austria
Funder
Wellcome Trust
FP7 Ideas: European Research Council
Boehringer Ingelheim
Publisher
American Chemical Society (ACS)
Subject
Molecular Medicine,General Medicine,Biochemistry
Link
http://pubs.acs.org/doi/pdf/10.1021/acschembio.9b00092
Reference30 articles.
1. Targeted Protein Degradation by Small Molecules
2. Structural basis of PROTAC cooperative recognition for selective protein degradation
3. A Comprehensive Mathematical Model for Three-Body Binding Equilibria
4. Targeted protein degradation and the enzymology of degraders
5. Protac-Induced Protein Degradation in Drug Discovery: Breaking the Rules or Just Making New Ones?
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