SPR-Measured Dissociation Kinetics of PROTAC Ternary Complexes Influence Target Degradation Rate-Reference-Cited by-同舟云学术

SPR-Measured Dissociation Kinetics of PROTAC Ternary Complexes Influence Target Degradation Rate

Published:2019-02-05 Issue:3 Volume:14 Page:361-368
ISSN:1554-8929
Container-title:ACS Chemical Biology
language:en
Short-container-title:ACS Chem. Biol.

Author:

Roy Michael J.¹,Winkler Sandra²,Hughes Scott J.¹,Whitworth Claire¹,Galant Michael²,Farnaby William¹,Rumpel Klaus²,Ciulli Alessio¹^ORCID

Affiliation:

1. Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, James Black Centre, Dow Street, Dundee DD1 5EH, United Kingdom

2. Boehringer Ingelheim RCV GmbH & Co KG, 1221 Vienna, Austria

Funder

Wellcome Trust

FP7 Ideas: European Research Council

Boehringer Ingelheim

Publisher

American Chemical Society (ACS)

Subject

Molecular Medicine,General Medicine,Biochemistry

Link

http://pubs.acs.org/doi/pdf/10.1021/acschembio.9b00092

Reference30 articles.

1. Targeted Protein Degradation by Small Molecules

2. Structural basis of PROTAC cooperative recognition for selective protein degradation

3. A Comprehensive Mathematical Model for Three-Body Binding Equilibria

4. Targeted protein degradation and the enzymology of degraders

5. Protac-Induced Protein Degradation in Drug Discovery: Breaking the Rules or Just Making New Ones?

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