Targeted Proteomics Combined with Affinity Mass Spectrometry Analysis Reveals Antagonist E7 Acts As an Intracellular Covalent Ligand of Orphan Receptor GPR52

Author:

Ma Mengna12,Guo Shimeng3,Lin Xi1,Li Shanshan1,Wu Yiran1,Zeng Yanping4,Hu Youhong45ORCID,Zhao Suwen1ORCID,Xu Fei1,Xie Xin356,Shui Wenqing1ORCID

Affiliation:

1. iHuman Institute, School of Life Science and Technology, ShanghaiTech University, 201210, Shanghai, China

2. University of Chinese Academy of Sciences, 100049, Beijing, China

3. School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210046, China

4. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China

5. School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, UCAS, Hangzhou 310024, China

6. CAS Laboratory of Receptor Research, The National Center for Drug Screening, Shanghai Institute of Materia Medica, 201203, Shanghai, China

Funder

Ministry of Science and Technology of the People's Republic of China

ShanghaiTech University

National Natural Science Foundation of China

National Science and Technology Major Projects for New Drug Development

Publisher

American Chemical Society (ACS)

Subject

Molecular Medicine,General Medicine,Biochemistry

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