Revisiting the Catalytic Cycle and Kinetic Mechanism of Aminoglycoside O-Nucleotidyltransferase(2″): A Structural and Kinetic Study

Author:

Bassenden Angelia V.12ORCID,Park Jaeok12ORCID,Rodionov Dmitry12,Berghuis Albert M.132

Affiliation:

1. Department of Biochemistry, McGill University, McIntyre Medical Building, 3655 Promenade Sir William Osler, Montréal, Québec Canada, H3G 1Y6

2. Centre de Recherche en Biologie Structurale, McGill University, Bellini Life Science Complex, 3649 Promenade Sir William Osler, Montréal, Québec Canada, H3G 0B1

3. Department of Microbiology and Immunology, McGill University, Duff Medical Building, 3775 University Street, Montréal, Québec Canada, H3A 2B4

Funder

Government of Canada

Fonds de Recherche du Qu??bec - Sant??

McGill University

Fonds de Recherche du Qu??bec - Nature et Technologies

Publisher

American Chemical Society (ACS)

Subject

Molecular Medicine,General Medicine,Biochemistry

Reference43 articles.

1. World Health Organization. (accessed 2019-07-10) Antimicrobial Resistance: Global Report on Surveillance, https://apps.who.int/iris/bitstream/handle/10665/112642/9789241564748_eng.pdf?sequence=1.

2. Aminoglycoside Antibiotics in the 21st Century

3. Drug-target networks in aminoglycoside resistance: hierarchy of priority in structural drug design

4. Aminoglycoside modifying enzymes

Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Inducible auto-phosphorylation regulates a widespread family of nucleotidyltransferase toxins;Nature Communications;2024-09-04

2. Countering Aminoglycoside Modifying Enzymes;Advances in Medical Technologies and Clinical Practice;2024-04-01

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