Application of a Sulfoxonium Ylide Electrophile to Generate Cathepsin X-Selective Activity-Based Probes

Author:

Mountford Simon J.1,Anderson Bethany M.23,Xu Bangyan2,Tay Elean S. V.2,Szabo Monika1,Hoang My-Linh1,Diao Jiayin3,Aurelio Luigi1,Campden Rhiannon I.4,Lindström Erik5,Sloan Erica K.3,Yates Robin M.4,Bunnett Nigel W.367,Thompson Philip E.1ORCID,Edgington-Mitchell Laura E.238ORCID

Affiliation:

1. Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia

2. Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, Victoria 3052, Australia

3. Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia

4. Snyder Institute for Chronic Disease and Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, Alberta T2N 1N4, Canada

5. Medivir AB, Huddinge, 141 22, Sweden

6. Department of Craniofacial Biology, New York University College of Dentistry, New York, New York 10010, United States

7. Department of Pharmacology and Experimental Therapeutics, The University of Melbourne, Parkville, Victoria 3052, Australia

8. Department of Oral and Maxillofacial Surgery, Bluestone Center for Clinical Research, New York University College of Dentistry, New York, New York 10010, United States

Funder

Monash University

Australian Research Council

U.S. Department of Defense

University of Melbourne

National Institutes of Health

National Medical Health & Medical Research Council

Publisher

American Chemical Society (ACS)

Subject

Molecular Medicine,General Medicine,Biochemistry

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