Discovery of the First Human Arylsulfatase A Reversible Inhibitor Impairing Mouse Oocyte Fertilization

Author:

Caroselli Silvia1,Zwergel Clemens23ORCID,Pirolli Adele24,Sabatino Manuela2,Xu Zhanjie5,Kirsch Gilbert5,Mai Antonello26ORCID,Colotti Gianni7,Altieri Fabio8,Canipari Rita1,Valente Sergio2ORCID,Ragno Rino29ORCID

Affiliation:

1. Department of Anatomy, Histology, Forensic Medicine and Orthopaedics, Section of Histology and Medical Embryology, Sapienza University of Rome, Via A. Scarpa 16, 00161 Rome, Italy

2. Department of Drug Chemistry and Technologies, Sapienza University of Rome, P. le A. Moro 5, 00185 Rome, Italy

3. Department of Precision Medicine, Luigi Vanvitelli, University of Campania, Via L. De Crecchio 7, 80138 Naples, Italy

4. Department of Information Technology, IRBM Science Park, Via Pontina km 30, 600, 00071 Pomezia, Rome, Italy

5. Université de Lorraine, UMR CNRS 7565, Structure et Réactivité des Systèmes Moléculaires Complexes, Equipe 3 (HECRIN), 1 Boulevard Arago, 57078, Metz Technopôle, France

6. Istituto Pasteur-Fondazione Cenci Bolognetti, Sapienza Università di Roma, Viale Regina Elena 291, 00161 Rome, Italy

7. Institute of Molecular Biology and Pathology, Italian National Research Council, c/o Department of Biochemical Sciences “Alessandro Rossi Fanelli”, Sapienza University of Rome, P. le A. Moro 5, 00185 Rome, Italy

8. Department of Biochemical Sciences “Alessandro Rossi Fanelli”, Sapienza University of Rome, P. le A. Moro 5, 00185 Rome, Italy

9. Rome Center for Molecular Design, Department of Drug Chemistry and Technologies, Sapienza University of Rome, P. le A. Moro 5, 00185 Rome, Italy

Funder

Sapienza Universit?? di Roma

KOHR GmbH

Publisher

American Chemical Society (ACS)

Subject

Molecular Medicine,General Medicine,Biochemistry

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