Understanding Cytotoxicity and Cytostaticity in a High-Throughput Screening Collection-Reference-Cited by-同舟云学术

Understanding Cytotoxicity and Cytostaticity in a High-Throughput Screening Collection

Published:2016-09-13 Issue:11 Volume:11 Page:3007-3023
ISSN:1554-8929
Container-title:ACS Chemical Biology
language:en
Short-container-title:ACS Chem. Biol.

Author:

Mervin Lewis H.¹,Cao Qing²,Barrett Ian P.³,Firth Mike A.³,Murray David⁴,McWilliams Lisa⁴,Haddrick Malcolm⁴,Wigglesworth Mark⁴,Engkvist Ola⁵,Bender Andreas¹

Affiliation:

1. Centre for Molecular Informatics, Department of Chemistry, University of Cambridge, Cambridge, United Kingdom

2. Discovery Sciences, AstraZeneca R&D, Waltham, United States

3. Discovery Sciences, AstraZeneca R&D, Cambridge Science Park, Cambridge, United Kingdom

4. Discovery Sciences, AstraZeneca R&D, Alderley Park, Macclesfield, United Kingdom

5. Discovery Sciences, AstraZeneca R&D, Mölndal, Sweden

Funder

AstraZeneca

Biotechnology and Biological Sciences Research Council

Publisher

American Chemical Society (ACS)

Subject

Molecular Medicine,General Medicine,Biochemistry

Link

http://pubs.acs.org/doi/pdf/10.1021/acschembio.6b00538

Reference67 articles.

1. Impact of high-throughput screening in biomedical research

2. Clinical development success rates for investigational drugs

3. Increasing the delivery of next generation therapeutics from high throughput screening libraries

4. Towards a hit for every target

5. An analysis of the attrition of drug candidates from four major pharmaceutical companies

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