Characterization of Binding Mode of Action of a Blocking Anti-Platelet-Derived Growth Factor (PDGF)-B Monoclonal Antibody, MOR8457, Reveals Conformational Flexibility and Avidity Needed for PDGF-BB To Bind PDGF Receptor-β-Reference-Cited by-同舟云学术

Characterization of Binding Mode of Action of a Blocking Anti-Platelet-Derived Growth Factor (PDGF)-B Monoclonal Antibody, MOR8457, Reveals Conformational Flexibility and Avidity Needed for PDGF-BB To Bind PDGF Receptor-β

Published:2015-03-06 Issue:10 Volume:54 Page:1918-1929
ISSN:0006-2960
Container-title:Biochemistry
language:en
Short-container-title:Biochemistry

Author:

Kuai Jun¹,Mosyak Lidia¹,Brooks Jon¹,Cain Michael¹,Carven Gregory J.²,Ogawa Shinji³,Ishino Tetsuya¹,Tam May¹,Lavallie Edward R.¹,Yang Zhiyong¹,Ponsel Dirk⁴,Rauchenberger Robert⁵,Arch Robert⁶,Pullen Nick¹

Affiliation:

1. Pfizer Global Research & Development, 610 Main Street, Cambridge, Massachusetts 02139, United States

2. Scholar Rock LLC, 300 Technology Square, Cambridge, Massachusetts 02142, United States

3. Pfizer Japan Inc., 3-22-7 Yoyogi, Shibuya, Tokyo 151-8589, Japan

4. Roche Diagnostics GmbH, Nonnenwald 2, 82377 Penzberg, Germany

5. MorphoSys AG, Lena-Christ Strasse 48, 82152 Martinsried, Germany

6. Takeda Pharmaceuticals International Inc., One Takeda Parkway, Deerfield, Illinois 60015, United States

Funder

Pfizer

Publisher

American Chemical Society (ACS)

Subject

Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/bi5015425

Reference63 articles.

1. Role of PDGF in fibrotic diseases and systemic sclerosis

2. The PDGF family in renal fibrosis

3. Role of platelet-derived growth factors in physiology and medicine

4. Patients with IgA nephropathy exhibit high systemic PDGF-DD levels

5. PDGF-C Expression in the Developing and Normal Adult Human Kidney and in Glomerular Diseases

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