Design, Synthesis, Radiolabeling, and in Vitro and in Vivo Evaluation of Bridgehead Iodinated Analogues of N-{2-[4-(2-Methoxyphenyl)piperazin-1-yl]ethyl}-N-(pyridin-2-yl)cyclohexanecarboxamide (WAY-100635) as Potential SPECT Ligands for the 5-HT1A Receptor-Reference-Cited by-同舟云学术

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Design, Synthesis, Radiolabeling, and in Vitro and in Vivo Evaluation of Bridgehead Iodinated Analogues of N-{2-[4-(2-Methoxyphenyl)piperazin-1-yl]ethyl}-N-(pyridin-2-yl)cyclohexanecarboxamide (WAY-100635) as Potential SPECT Ligands for the 5-HT1A Receptor

Published:2011-04-26 Issue:10 Volume:54 Page:3480-3491
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Al Hussainy Rana¹,Verbeek Joost¹,van der Born Dion¹,Braker Anton H.¹,Leysen Josée E.¹,Knol Remco J.²,Booij Jan²,Herscheid J. (Koos) D. M.¹

Affiliation:

1. Department of Nuclear Medicine and PET Research, VU University Medical Center, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands

2. Department of Nuclear Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm1009956

Reference52 articles.

1. Inhibition of cAMP Accumulation Via Recombinant Human Serotonin 5-HT 1A Receptors: Considerations on Receptor Effector Coupling across Systems

2. Subtypes of Receptors for Serotonin

3. Visualisation of serotonin-1A (5-HT1A) receptors in the central nervous system

4. Serotonin receptors: Subtypes, functional responses and therapeutic relevance

5. Psychopharmacology of 5-HT1A receptors

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