Design of HIV-1 Protease Inhibitors with C3-Substituted Hexahydrocyclopentafuranyl Urethanes as P2-Ligands: Synthesis, Biological Evaluation, and Protein–Ligand X-ray Crystal Structure-Reference-Cited by-同舟云学术

Design of HIV-1 Protease Inhibitors with C3-Substituted Hexahydrocyclopentafuranyl Urethanes as P2-Ligands: Synthesis, Biological Evaluation, and Protein–Ligand X-ray Crystal Structure

Published:2011-07-29 Issue:16 Volume:54 Page:5890-5901
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Ghosh Arun K.¹,Chapsal Bruno D.¹,Parham Garth L.¹,Steffey Melinda¹,Agniswamy Johnson²,Wang Yuan-Fang²,Amano Masayuki³,Weber Irene T.²,Mitsuya Hiroaki³⁴

Affiliation:

1. Departments of Chemistry and Medicinal Chemistry, Purdue University, West Lafayette, Indiana 47907, United States

2. Department of Biology, Molecular Basis of Disease, Georgia State University, Atlanta, Georgia 30303, United States

3. Departments of Hematology and Infectious Diseases, Kumamoto University Graduate School of Medical and Pharmaceutical Sciences, Kumamoto 860-8556, Japan

4. Experimental Retrovirology Section, HIV and AIDS Malignancy Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm200649p

Reference33 articles.

1. Declining Morbidity and Mortality among Patients with Advanced Human Immunodeficiency Virus Infection

2. AIDS — The First 20 Years

3. Emergence of Drug Resistance in HIV Type 1–Infected Patients after Receipt of First‐Line Highly Active Antiretroviral Therapy: A Systematic Review of Clinical Trials

4. Public Health Implications of Antiretroviral Therapy and HIV Drug Resistance

5. Design of HIV Protease Inhibitors Targeting Protein Backbone: An Effective Strategy for Combating Drug Resistance

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