Design, Synthesis, and X-ray Crystal Structure of a Potent Dual Inhibitor of Thymidylate Synthase and Dihydrofolate Reductase as an Antitumor Agent-Reference-Cited by-同舟云学术

Design, Synthesis, and X-ray Crystal Structure of a Potent Dual Inhibitor of Thymidylate Synthase and Dihydrofolate Reductase as an Antitumor Agent

Published:2000-09-13 Issue:21 Volume:43 Page:3837-3851
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Gangjee Aleem¹,Yu Jianming¹,McGuire John J.¹,Cody Vivian¹,Galitsky Nikolai¹,Kisliuk Roy L.¹,Queener Sherry F.¹

Affiliation:

1. Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, Pennsylvania 15282; Grace Cancer Drug Center, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, New York 14263; Hauptman−Woodward Medical Research Institute, Inc., 73 High Street, Buffalo, New York 14203; Department of Biochemistry, Tufts University School of Medicine, Boston, Massachusetts 02111; and Department of Pharmacology and Toxicology, School of Medicine, Indiana University...

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm000200l

Reference85 articles.

1. (a) Presented in part at the 214th American Chemical Society National Meeting, Boston, MA, Aug 23−27, 1998; Abstr. MEDI 332.

2. (b) Presented in part at the International Union of Crystallography Congress, Glasgow, Scotland, U.K., Aug 4−13, 1999.

3. The renewed potential for folate antagonists in contemporary cancer chemotherapy

Cited by 83 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Prediction of lung adenocarcinoma prognosis and diagnosis with a novel model anchored in circadian clock-related genes;Scientific Reports;2024-08-06

2. Transparent, colourless, ultra-fast room-temperature self-healing polyurethane with potential for self-repairable electrode;Polymer;2024-08

3. Stability of Ti ₃ C ₂ -MXene/Waterborne polyurethane composite emulsion and investigation of visible light-driven film self-healing performance;Advanced Composite Materials;2024-04-09

4. Transparent, Colourless, Ultra-Fast Room-Temperature Self-Healing Polyurethane with Potential for Self-Repairable Electrode;2024

5. Strain-Hardening, impact protective and Self-Healing supramolecular polyurethane nanocomposites enabled by quadruple H-Bonding, disulfide bonds and nanoparticles;Chemical Engineering Journal;2023-07