1. Department of Neurosciences and Biomedical Technologies, University of Milan “Bicocca”, 20052 Monza, Italy, Department of Biochemistry and Molecular Biology “Ernesto Quagliariello”, University of Bari, 70126 Bari, Italy, MediGene AG, 82152 Martinsried, Germany, and Department of Biology D.B.A.F., University of Basilicata, 85100 Potenza, Italy