Light-Induced Cytosolic Activation of Reduction-Sensitive Camptothecin-Loaded Polymeric Micelles for Spatiotemporally Controlled in Vivo Chemotherapy

Author:

Yen Hung-Chi1,Cabral Horacio1,Mi Peng2,Toh Kazuko3,Matsumoto Yu3,Liu Xueying3,Koori Hiroshi4,Kim Ahram1,Miyazaki Kozo3,Miura Yutaka3,Nishiyama Nobuhiro2,Kataoka Kazunori1356

Affiliation:

1. Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan

2. Polymer Chemistry Division, Chemical Resources Laboratory, Tokyo Institute of Technology, R1-11, 4259 Nagatsuta, Midori-ku, Yokohama 226-8503, Japan

3. Division of Clinical Biotechnology, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan

4. Pharmaceutical & Healthcare Research Laboratories, Research & Development Management Headquarters, Fujifilm Company, Ltd., 577 Ushijima, Kaiseimachi, Ashigarakami-gun, Kanagawa 258-8577, Japan

5. Department of Materials Engineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan

6. Kawasaki Institute of Industry Promotion, 66-20 Horikawa-cho, Saiwai-ku, Kawasaki 212-0013, Japan

Funder

Ministry of Education, Culture, Sports, Science, and Technology

Japan Society for the Promotion of Science

Japan Science and Technology Agency

Ministry of Health, Labour and Welfare

Takeda Science Foundation

Publisher

American Chemical Society (ACS)

Subject

General Physics and Astronomy,General Engineering,General Materials Science

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