Roughing It: A Mantellid Poison Frog Shows Greater Alkaloid Diversity in Some Disturbed Habitats

Author:

Andriamaharavo Nirina R.1,Garraffo H. Martin1,Saporito Ralph A.1,Daly John W.1,Razafindrabe Christian R.1,Andriantsiferana Marta1,Spande Thomas F.1

Affiliation:

1. Laboratory of Bioorganic Chemistry, NIDDK, NIH, DHHS, Bethesda, Maryland 20892, Department of Biological Sciences, Old Dominion University, Norfolk, Virginia 23529, and Laboratoire de Chimie Organique “Produits Naturels”, Université d’Antananarivo, Antananarivo 101, Madagascar

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Complementary and alternative medicine,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Analytical Chemistry

Reference24 articles.

1. Alkaloids from Amphibian Skin:  A Tabulation of Over Eight-Hundred Compounds

2. Occurrence of skin alkaloids in non-dendrobatid frogs from Brazil (Bufonidae), Australia (Myobatrachidae) and Madagascar (Mantellinae)

3. This study included specimens ofM. madagascariensis(n= 1) andM. aurantiaca(n= 5) and constituted the first study of mantellids by Daly and co-workers. Specimens were acquired in the U.S. Pumiliotoxins and decahydroquinolines seen also in dendrobatids were identified by EIMS, but some alkaloids (e.g.235C,241B,251G) were and still remain unique to mantellids. Only the pumiliotoxins from that study were seen in the present study.

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