Double-Headed Sulfur-Linked Amino Acids As First Inhibitors for Betaine-Homocysteine S-Methyltransferase 2-Reference-Cited by-同舟云学术

Double-Headed Sulfur-Linked Amino Acids As First Inhibitors for Betaine-Homocysteine S-Methyltransferase 2

Published:2012-07-18 Issue:15 Volume:55 Page:6822-6831
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Mládková Jana¹,Vaněk Václav¹,Buděšínský Miloš¹,Elbert Tomáš¹,Demianová Zuzana¹,Garrow Timothy A.²,Jiráček Jiří¹

Affiliation:

1. Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, v.v.i., Flemingovo nám. 2, 166 10 Prague 6, Czech Republic

2. Department of Food Science and Human Nutrition, University of Illinois, Urbana, Illinois 61801, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm300571h

Reference32 articles.

1. The Many Flavors of Hyperhomocyst(e)inemia: Insights from Transgenic and Inhibitor-Based Mouse Models of Disrupted One-Carbon Metabolism

2. Methionine metabolism in mammals. Distribution of homocysteine between competing pathways.

3. Betaine-Homocysteine Methyltransferase

4. Crystal Structure of Rat Liver Betaine Homocysteine S-Methyltransferase Reveals New Oligomerization Features and Conformational Changes Upon Substrate Binding

5. Inhibition of Betaine-Homocysteine S-Methyltransferase Causes Hyperhomocysteinemia in Mice

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1. A Review of Small-Molecule Inhibitors of One-Carbon Enzymes: SHMT2 and MTHFD2 in the Spotlight;ACS Pharmacology & Translational Science;2021-03-01

2. Metabolism of Sulfur-Containing Amino Acids: How the Body Copes with Excess Methionine, Cysteine, and Sulfide;The Journal of Nutrition;2020-10-01

3. Specific potassium ion interactions facilitate homocysteine binding to betaine-homocysteine S -methyltransferase;Proteins: Structure, Function, and Bioinformatics;2014-06-17

4. The development of a new class of inhibitors for betaine-homocysteine S-methyltransferase;European Journal of Medicinal Chemistry;2013-07

5. Correction to Double-Headed Sulfur-Linked Amino Acids As First Inhibitors for Betaine-Homocysteine S-Methyltransferase 2;Journal of Medicinal Chemistry;2012-10-03