Synthesis and Biological Profile of the Enantiomers of [4-(4-Amino-6,7-dimethoxyquinazolin-2-yl)-cis-octahydroquinoxalin-1-yl]furan- 2-ylmethanone (Cyclazosin), a Potent Competitive α1B-Adrenoceptor Antagonist-Reference-Cited by-同舟云学术

Synthesis and Biological Profile of the Enantiomers of [4-(4-Amino-6,7-dimethoxyquinazolin-2-yl)-cis-octahydroquinoxalin-1-yl]furan- 2-ylmethanone (Cyclazosin), a Potent Competitive α1B-Adrenoceptor Antagonist

Published:1996-01-01 Issue:23 Volume:39 Page:4602-4607
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Giardinà Dario¹,Crucianelli Mauro¹,Romanelli Roberta¹,Leonardi Amedeo¹,Poggesi Elena¹,Melchiorre Carlo¹

Affiliation:

1. Department of Chemical Sciences, University of Camerino, Via S. Agostino 1, 62032 Camerino, Italy, Pharmaceutical R & D Division, Recordati S.p.A., Via Civitali 1, 20148 Milano, Italy, and Department of Pharmaceutical Sciences, University of Bologna,Via Belmeloro 6, 40126 Bologna, Italy

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm960510x

Reference30 articles.

1. .alpha.- and .beta.-Adrenoceptors: From the Gene to the Clinic. Part 1. Molecular Biology and Adrenoceptor Subclassification

2. BMY 7378 is a selective antagonist of the D subtype of α1-adrenoceptors

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