Bioactivation of the Cannabinoid Receptor Antagonist Rimonabant to a Cytotoxic Iminium Ion Metabolite
Author:
Affiliation:
1. CVGI Innovative Medicine DMPK, AstraZeneca, Mölndal 431 83, Sweden
2. Department of Chemistry, Virginia Tech, Blacksburg, Virginia 24061, United States
Publisher
American Chemical Society (ACS)
Subject
Toxicology,General Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/tx300418w
Reference38 articles.
1. Update on Rimonabant—A Selective Cannabinoid CB1 Antagonist
2. Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1-year experience from the RIO-Europe study
3. Efficacy and tolerability of rimonabant in overweight or obese patients with type 2 diabetes: a randomised controlled study
4. Efficacy and safety of the weight-loss drug rimonabant: a meta-analysis of randomised trials
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