1. Department of Chemistry and Umeå Centre for Microbial Research, Umeå University, SE-90187 Umeå, Sweden, ACADIA Pharmaceuticals Inc., 3911 Sorrento Valley Boulevard, San Diego, California 92121, United States, Department of Chemistry and Molecular Biology, University of Gothenburg, SE-41296 Gothenburg, Sweden, and Department of Experimental Medical Science, Lund University, SE-22100, Lund, Sweden