Carbamoyl Pyridone HIV-1 Integrase Inhibitors. 1. Molecular Design and Establishment of an Advanced Two-Metal Binding Pharmacophore-Reference-Cited by-同舟云学术

Carbamoyl Pyridone HIV-1 Integrase Inhibitors. 1. Molecular Design and Establishment of an Advanced Two-Metal Binding Pharmacophore

Published:2012-10-04 Issue:20 Volume:55 Page:8735-8744
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Kawasuji Takashi¹,Johns Brian A.²,Yoshida Hiroshi¹,Taishi Teruhiko¹,Taoda Yoshiyuki¹,Murai Hitoshi¹,Kiyama Ryuichi¹,Fuji Masahiro¹,Yoshinaga Tomokazu¹,Seki Takahiro¹,Kobayashi Masanori¹,Sato Akihiko¹,Fujiwara Tamio¹

Affiliation:

1. Shionogi Pharmaceutical Research Center, Shionogi & Co., Ltd., 3-1-1 Futaba-cho, Toyonaka-shi, Osaka 561-0825, Japan

2. GlaxoSmithKline Research & Development, Infectious Diseases Therapeutic Area Unit, Five Moore Drive, Research Triangle Park, North Carolina 27709, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm3010459

Reference39 articles.

1. New anti-HIV agents and targets

2. Highlights in the Development of New Antiviral Agents

3. Targeting HIV: Old and New Players

4. Structure and Function of HIV-1 Integrase

5. HIV Integrase, a Brief Overview from Chemistry to Therapeutics

Cited by 56 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Design, synthesis, molecular dynamics studies and biological evaluations of 4-hydroxy-5-pyrrolinone-3-carbohydrazides as HIV-1 integrase inhibitors;European Journal of Medicinal Chemistry Reports;2024-12

2. Molecular design and evaluation of aza-polycyclic carbamoyl pyridones as HIV-1 integrase strand transfer inhibitors;Bioorganic & Medicinal Chemistry Letters;2024-10

3. Cabotegravir (Vocabria): An HIV Integrase Strand Transfer Inhibitor for Treating HIV Infection;Chemistry and Pharmacology of Drug Discovery;2024-08-16

4. N-Substituted Bicyclic Carbamoyl Pyridones: Integrase Strand Transfer Inhibitors that Potently Inhibit Drug-Resistant HIV-1 Integrase Mutants;ACS Infectious Diseases;2024-02-12

5. Fluorine in anti-HIV drugs approved by FDA from 1981 to 2023;European Journal of Medicinal Chemistry;2023-10