1. Department of Pharmaceutical Sciences, College of Pharmacy, The University of Michigan, Ann Arbor, Michigan 48109-1065, Department of Medicine, University of Washington, Seattle, Washington 98195-7720, Division of Gastroenterology, Department of Internal Medicine, The University of Michigan, Ann Arbor, Michigan 48109-0682, and Division of Rheumatology, Department of Internal Medicine, The University of Michigan, Ann Arbor, Michigan 48109-0688