1-Oxo-1H-phenalene-2,3-dicarbonitrile Heteroaromatic Scaffold: Revised Structure and Mechanistic Studies

Author:

Lenk Romaric1,Tessier Arnaud1,Lefranc Pierre1,Silvestre Virginie1,Planchat Aurélien1,Blot Virginie1,Dubreuil Didier1,Lebreton Jacques1

Affiliation:

1. Université de Nantes, CNRS, CEISAM, UMR CNRS 6230, Faculté des Sciences et des Techniques, 2 rue de la Houssinière, BP 92208, 44322 Nantes Cedex 3, France

Funder

Centre National de la Recherche Scientifique

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Reference42 articles.

1. Part of this present work was published in the following patent:Lebreton, J.; Lenk, R.; Dubreuil, D.; Silvestre, V.; Planchat. A.Preparation of oxophenalene compounds and their uses in therapy and material fields. Brevet international WO 2013128425 A1 20130906, 2013. This patent was accessible on the 12th of September, 2013. During the completion on this work, in particular the mechanism studies reported in the present article, a correction of all of the structures prepared by the group of Qian appeared in the literature (amendment published online on the 23rd of November, 2013) without citing the work mentioned in our patent, see:

2. Correction to Acenaphtho[1,2-b]pyrrole-Based Selective Fibroblast Growth Factor Receptors 1 (FGFR1) Inhibitors: Design, Synthesis, and Biological Activity

3. Chem. Commun. 2014, 50, 9596–9598.

4. Correction to 3-Thiomorpholin-8-oxo-8H-acenaphtho[1,2-b]pyrrole-9-carbonitrile (S1) Based Molecules as Potent, Dual Inhibitors of B-Cell Lymphoma 2 (Bcl-2) and Myeloid Cell Leukemia Sequence 1 (Mcl-1): Structure-Based Design and Structure–Activity Relationship Studies

5. 1,3,4-Thiadiazole: Synthesis, Reactions, and Applications in Medicinal, Agricultural, and Materials Chemistry

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