Synthesis and SAR Investigations for Novel Melanin-Concentrating Hormone 1 Receptor (MCH1) Antagonists Part 2: A Hybrid Strategy Combining Key Fragments of HTS Hits-Reference-Cited by-同舟云学术

Synthesis and SAR Investigations for Novel Melanin-Concentrating Hormone 1 Receptor (MCH1) Antagonists Part 2: A Hybrid Strategy Combining Key Fragments of HTS Hits

Published:2007-08-01 Issue:16 Volume:50 Page:3883-3890
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Chen Chien-An¹,Jiang Yu¹,Lu Kai¹,Daniewska Irena¹,Mazza Christine G.¹,Negron Leonardo¹,Forray Carlos¹,Parola Tony¹,Li Boshan¹,Hegde Laxminarayan G.¹,Wolinsky Toni D.¹,Craig Douglas A.¹,Kong Ron¹,Wetzel John M.¹,Andersen Kim¹,Marzabadi Mohammad R.¹

Affiliation:

1. Departments of Chemistry, Cellular Science and Target Discovery and Assessment, Lundbeck Research USA, Inc., 215 College Road, Paramus, New Jersey 07652-1413

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm060383x

Reference46 articles.

1. Characterization of melanin-concentrating hormone in chum salmon pituitaries

2. The melanin-concentrating hormone system of the rat brain: An immuno- and hybridization histochemical characterization

3. Identification of melanin concentrating hormone (MCH) as the natural ligand for the orphan somatostatin-like receptor 1 (SLC-1)

4. Melanin-concentrating hormone is the cognate ligand for the orphan G-protein-coupled receptor SLC-1

5. The receptor for the orexigenic peptide melanin-concentrating hormone is a G-protein-coupled receptor

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