Discovery of the First Highly M5-Preferring Muscarinic Acetylcholine Receptor Ligand, an M5 Positive Allosteric Modulator Derived from a Series of 5-Trifluoromethoxy N-Benzyl Isatins-Reference-Cited by-同舟云学术

Discovery of the First Highly M5-Preferring Muscarinic Acetylcholine Receptor Ligand, an M5 Positive Allosteric Modulator Derived from a Series of 5-Trifluoromethoxy N-Benzyl Isatins

Published:2009-05-13 Issue:11 Volume:52 Page:3445-3448
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Bridges Thomas M.¹,Marlo Joy E.¹,Niswender Colleen M.¹,Jones Carrie K.¹,Jadhav Satyawan B.¹,Gentry Patrick R.¹,Plumley Hyekyung C.¹,Weaver C. David¹,Conn P. Jeffrey¹,Lindsley Craig W.¹

Affiliation:

1. Vanderbilt Program in Drug Discovery, Departments of Pharmacology and Chemistry, Vanderbilt University Medical Center, 1205 LH, Nashville, Tennessee, 37232-0697

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm900286j

Reference14 articles.

1. Identification of a Family of Muscarinic Acetylcholine Receptor Genes

2. Cloning and expression of the human and rat m5 muscarinic acetylcholine receptor genes

3. Muscarinic Acetylcholine Receptor Knockout Mice: Novel Phenotypes and Clinical Implications

4. Muscarinic acetylcholine receptors as CNS drug targets

5. Allosterism at Muscarinic Receptors: Ligands and Mechanisms

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