Synthesis and Biological Evaluation of 1,2,4-Triazinylphenylalkylthiazolecarboxylic Acid Esters as Cytokine-Inhibiting Antedrugs with Strong Bronchodilating Effects in an Animal Model of Asthma-Reference-Cited by-同舟云学术

Synthesis and Biological Evaluation of 1,2,4-Triazinylphenylalkylthiazolecarboxylic Acid Esters as Cytokine-Inhibiting Antedrugs with Strong Bronchodilating Effects in an Animal Model of Asthma

Published:2004-12-29 Issue:6 Volume:48 Page:2167-2175
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Freyne Eddy J.¹,Lacrampe Jean F.¹,Deroose Frederik¹,Boeckx Gustaaf M.¹,Willems Marc¹,Embrechts Werner¹,Coesemans Erwin¹,Willems Johan J.¹,Fortin Jerome M.¹,Ligney Yannick¹,Dillen Lieve L.¹,Cools Willy F.¹,Goossens Jan¹,Corens David¹,De Groot Alex¹,Van Wauwe Jean P.¹

Affiliation:

1. Medicinal Chemistry Department and Department of Inflammation, Johnson & Johnson Pharmaceutical Research and Development, a Division of Janssen Pharmaceutica N.V., Turnhoutseweg 30, B-2340 Beerse, Belgium, and Campus de Maigremont BP 615, 27106 Val de Reuil, France

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm049479m

Reference26 articles.

1. Epidemiology of childhood asthma

2. CC chemokines in allergic inflammation

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