1. Total synthesis of the latrunculins
2. The Use of Diethyl Azodicarboxylate and Triphenylphosphine in Synthesis and Transformation of Natural Products
3. The synthesis of phosphonate esters; an extension of the Mitsunobu reaction
4. A new stable Wittig reagent suitable for the synthesis of α,β-unsaturated phosphonates
5. Selected data for compounds are as follows.10a: Rf= 0.71 (silica gel, petroleum ether/ethyl acetate 1:1); FTIR (neat) 2927, 2859, 1593, 1490, 1458, 1380, 1253, 1210, 1163, 1071, 991, 920, 766 cm-1;1H NMR (400 MHz, CDCl3) δ 7.05−7.38 (m, 5H), 4.75 (m, 1H), 1.24−1.88 (m, 22H), 1.22 (d,J= 6.3 Hz, 3H);31P NMR (81 MHz, CDCl3) δ 29.6; HRMS calcd for C19H31O3P 338.2011, found 338.2002. Anal. Calcd for C19H31O3P: C, 67.42; H, 9.24. Found: C, 67.20; H, 9.20.10b: mp 97−99 °C.Rf= 0.57 (silica gel, petroleum ether/ethyl acetate 1:1); FTIR (CDCl3) 2932, 2860, 1593, 1492, 1456, 1223, 1011 cm-1;1H NMR (400 MHz, CDCl3) δ 7.05−7.38 (m, 5H), 4.65 (m, 1H), 1.93 (m, 2H), 1.20−1.73 (m, 20H), 1.43 (d,J= 6.2 Hz, 3H);31P NMR (81 MHz, CDCl3) δ 27.8; HRMS calcd for C19H31O3P 338.2011, found 338.2009. Anal. Calcd for C19H31O3P: C, 67.42; H, 9.24. Found: C, 67.15; H, 9.39.11: mp 103−105 °C;Rf= 0.62 (silica gel, petroleum ether/ethyl acetate 1:1); FTIR (CDCl3) 2930, 2856, 1593, 1491, 1229, 1012 cm-1;1H NMR (400 MHz, CDCl3) δ 7.10−7.33 (m, 10H), 4.66 (m, 2H), 1.84 (m, 4H), 1.68 (m, 4H), 1.56 (m, 4H), 1.20−1.45 (m, 40H), 1.15 (d,J= 6.2 Hz, 6H);31P NMR (81 MHz, CDCl3) δ 29.0; HRMS calcd for C38H62O6P2676.4022, found 676.4002. Anal. Calcd for C38H62O6P2: C, 67.42; H, 9.24. Found: C, 67.51; H, 9.28.