1. Department of Bioscience and Bioinformatics, Ritsumeikan University, Kusatsu, Shiga 525-8577, Japan, Department of Anesthesiology, Shiga University of Medical Science, Otsu, Shiga 520-2192, Japan, National Institute for Nanotechnology, National Research Council of Canada, and Department of Mechanical Engineering, University of Alberta, 11421 Saskatchewan Drive, Edmonton, Alberta T6G 2M9, Canada, and Department of Theoretical Studies, Institute for Molecular Science, Okazaki, Aichi 444-8585, Japan