Design, Synthesis, Evaluation, and Crystallographic-Based Structural Studies of HIV-1 Protease Inhibitors with Reduced Response to the V82A Mutation-Reference-Cited by-同舟云学术

Design, Synthesis, Evaluation, and Crystallographic-Based Structural Studies of HIV-1 Protease Inhibitors with Reduced Response to the V82A Mutation

Published:2008-01-24 Issue:4 Volume:51 Page:852-860
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Clemente José C.¹,Robbins Arthur¹,Graña Paula¹,Paleo M. Rita¹,Correa Juan F.¹,Villaverde M. Carmen¹,Sardina F. Javier¹,Govindasamy Lakshmanan¹,Agbandje-McKenna Mavis¹,McKenna Robert¹,Dunn Ben M.¹,Sussman Fredy¹

Affiliation:

1. Departamento de Química Orgánica, Facultad de Química, Universidad de Santiago de Compostela, 15782-Santiago de Compostela, Spain, and Department of Biochemistry and Molecular Biology, University of Florida College of Medicine, Gainesville, Florida 32610

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm701170f

Reference42 articles.

1. STRUCTURE-BASED INHIBITORS OF HIV-1 PROTEASE

2. Structural Mechanisms of HIV Drug Resistance

3. INHIBITORS OF HIV-1 PROTEASE: A Major Success of Structure-Assisted Drug Design

4. In vivo emergence of HIV-1 variants resistant to multiple protease inhibitors

5. Characterization of human immunodeficiency virus type 1 variants with increased resistance to a C2-symmetric protease inhibitor

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