Sulfonamidopyrrolidinone Factor Xa Inhibitors: Potency and Selectivity Enhancements via P-1 and P-4 Optimization-Reference-Cited by-同舟云学术

Sulfonamidopyrrolidinone Factor Xa Inhibitors: Potency and Selectivity Enhancements via P-1 and P-4 Optimization

Published:1999-08-17 Issue:18 Volume:42 Page:3572-3587
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Choi-Sledeski Yong Mi¹,McGarry Daniel G.¹,Green Daniel M.¹,Mason Helen J.¹,Becker Michael R.¹,Davis Roderick S.¹,Ewing William R.¹,Dankulich William P.¹,Manetta Vincent E.¹,Morris Robert L.¹,Spada Alfred P.¹,Cheney Daniel L.¹,Brown Karen D.¹,Colussi Dennis J.¹,Chu Valeria¹,Heran Christopher L.¹,Morgan Suzanne R.¹,Bentley Ross G.¹,Leadley Robert J.¹,Maignan Sebastien¹,Guilloteau Jean-Pierre¹,Dunwiddie Christopher T.¹,Pauls Henry W.¹

Affiliation:

1. Departments of Cardiovascular Drug Discovery and New Leads Generation, Rhône-Poulenc Rorer, 500 Arcola Road, Collegeville, Pennsylvania 19426-0107

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm990041%2B

Reference33 articles.

1. The coagulation cascade: initiation, maintenance, and regulation

2. Optimization of conditions for the catalytic effect of the factor IXa - Factor VIII complex

3. Cell Mediated Events that Control Blood Coagulation and Vascular Injury