Unique Overlap in the Prerequisites for Thrombin Inhibition and Oral Bioavailability Resulting in Potent Oral Antithrombotics-Reference-Cited by-同舟云学术

Unique Overlap in the Prerequisites for Thrombin Inhibition and Oral Bioavailability Resulting in Potent Oral Antithrombotics

Published:2002-08-30 Issue:20 Volume:45 Page:4419-4432
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Adang Anton E. P.¹,de Man Adrianus P. A.¹,Vogel Gerard M. T.¹,Grootenhuis Peter D. J.¹,Smit Martin J.¹,Peters Co A. M.¹,Visser Arie¹,Rewinkel Jos B. M.¹,van Dinther Theo¹,Lucas Hans¹,Kelder Jan¹,van Aelst Sjoerd¹,Meuleman Dick G.¹,van Boeckel Constant A. A.¹

Affiliation:

1. Research and Development, Lead Discovery Unit Chemistry Group, NV Organon, Lead Optimization Unit Pharmacology Department, NV Organon, DuPont Pharmaceuticals Research Laboratories, Lead Discovery Unit Assay Development Group, NV Organon, Lead Optmization Unit Medicinal Chemistry Department, NV Organon, and Department of Molecular Design and Informatics, NV Organon

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm011110z

Reference50 articles.

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2. Vasopressin receptor antagonism - a therapeutic option in heart failure and hypertension

3. Corticotropin-releasing factor antagonists in affective disorders

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