Benzimidazole-2-pyrazole HIF Prolyl 4-Hydroxylase Inhibitors as Oral Erythropoietin Secretagogues-Reference-Cited by-同舟云学术

Benzimidazole-2-pyrazole HIF Prolyl 4-Hydroxylase Inhibitors as Oral Erythropoietin Secretagogues

Published:2010-10-05 Issue:9 Volume:1 Page:526-529
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Rosen Mark D.¹,Venkatesan Hariharan¹,Peltier Hillary M.¹,Bembenek Scott D.¹,Kanelakis Kimon C.¹,Zhao Lucy X.¹,Leonard Barry E.¹,Hocutt Frances M.¹,Wu Xiaodong¹,Palomino Heather L.¹,Brondstetter Theresa I.¹,Haugh Peter V.¹,Cagnon Laurence¹,Yan Wen¹,Liotta Lisa A.¹,Young Andrew¹,Mirzadegan Tara¹,Shankley Nigel P.¹,Barrett Terrance D.¹,Rabinowitz Michael H.¹

Affiliation:

1. Johnson & Johnson Pharmaceutical Research and Development, L.L.C, 3210 Merryfield Row, San Diego, California 92121, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/ml100198y

Reference27 articles.

1. HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O 2 Sensing

2. HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1 in normoxia

3. Oxygen sensing by HIF hydroxylases