Widespread Perturbation of Function, Structure, and Dynamics by a Conservative Single-Atom Substitution in Thymidylate Synthase-Reference-Cited by-同舟云学术

Widespread Perturbation of Function, Structure, and Dynamics by a Conservative Single-Atom Substitution in Thymidylate Synthase

Published:2016-09-30 Issue:40 Volume:55 Page:5702-5713
ISSN:0006-2960
Container-title:Biochemistry
language:en
Short-container-title:Biochemistry

Author:

Sapienza Paul J.¹,Lee Andrew L.¹

Affiliation:

1. Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States

Funder

National Institute of General Medical Sciences

Publisher

American Chemical Society (ACS)

Subject

Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.biochem.6b00838

Reference62 articles.

1. Thymidylate synthetase - a target enzyme in cancer chemotherapy

2. Deoxyribonucleotide metabolism, mutagenesis and cancer

3. Kinetic Scheme for Thymidylate Synthase from Escherichia coli: Determination from Measurements of Ligand Binding, Primary and Secondary Isotope Effects, and Pre-Steady-State Catalysis

4. Vibrationally Enhanced Hydrogen Tunneling in the Escherichia coli Thymidylate Synthase Catalyzed Reaction

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