Effects of Acyclovir, Foscarnet, and Ribonucleotides on Herpes Simplex Virus-1 DNA Polymerase: Mechanistic Insights and a Novel Mechanism for Preventing Stable Incorporation of Ribonucleotides into DNA-Reference-Cited by-同舟云学术

Effects of Acyclovir, Foscarnet, and Ribonucleotides on Herpes Simplex Virus-1 DNA Polymerase: Mechanistic Insights and a Novel Mechanism for Preventing Stable Incorporation of Ribonucleotides into DNA

Published:2016-02-11 Issue:7 Volume:55 Page:1168-1177
ISSN:0006-2960
Container-title:Biochemistry
language:en
Short-container-title:Biochemistry

Author:

Vashishtha Ashwani Kumar¹,Kuchta Robert D.¹

Affiliation:

1. Department of Chemistry and Biochemistry, University of Colorado, Boulder, Colorado 80309-0215, United States

Funder

National Institute of Allergy and Infectious Diseases

Publisher

American Chemical Society (ACS)

Subject

Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.biochem.6b00065

Reference52 articles.

1. Acyclovir-resistant mutants of herpes simplex virus type 1 express altered DNA polymerase or reduced acyclovir phosphorylating activities

2. Genetic mechanisms of resistance to acyclovir in herpes simplex virus

3. Resistance of herpes simplex virus to acycloguanosine—genetic and physical analysis

4. Biochemical and genetic analysis of acyclovir-resistant mutants of herpes simplex virus type 1

5. The enzymological basis for resistance of herpesvirus DNA polymerase mutants to acyclovir: Relationship to the structure of alpha -like DNA polymerases

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