Unveiling the Pathogenic Molecular Mechanisms of the Most Common Variant (p.K329E) in Medium-Chain Acyl-CoA Dehydrogenase Deficiency by in Vitro and in Silico Approaches-Reference-Cited by-同舟云学术

Unveiling the Pathogenic Molecular Mechanisms of the Most Common Variant (p.K329E) in Medium-Chain Acyl-CoA Dehydrogenase Deficiency by in Vitro and in Silico Approaches

Published:2016-12-15 Issue:51 Volume:55 Page:7086-7098
ISSN:0006-2960
Container-title:Biochemistry
language:en
Short-container-title:Biochemistry

Author:

Bonito Cátia A.¹^ORCID,Nunes Joana¹,Leandro João¹,Louro Filipa¹,Leandro Paula¹,Ventura Fátima V.¹,Guedes Rita C.¹

Affiliation:

1. Department of Biochemistry and Human Biology, §Medicinal Chemistry, Research Institute for Medicines, iMed.ULisboa, ‡Metabolism and Genetics Group, Research Institute for Medicines, iMed.ULisboa, and ∥Department of Pharmaceutical Chemistry and Therapeutics, Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal

Funder

Fundação para a Ciência e a Tecnologia

Publisher

American Chemical Society (ACS)

Subject

Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.biochem.6b00759

Reference64 articles.

1. Mitochondrial fatty acid oxidation defects—remaining challenges

2. Crystal structures of medium-chain acyl-CoA dehydrogenase from pig liver mitochondria with and without substrate.

3. Acyl-CoA dehydrogenases and acyl-CoA oxidases. Structural basis for mechanistic similarities and differences