N-Terminal Acetylation of α-Synuclein Slows down Its Aggregation Process and Alters the Morphology of the Resulting Aggregates-Reference-Cited by-同舟云学术

N-Terminal Acetylation of α-Synuclein Slows down Its Aggregation Process and Alters the Morphology of the Resulting Aggregates

Published:2022-08-09 Issue:17 Volume:61 Page:1743-1756
ISSN:0006-2960
Container-title:Biochemistry
language:en
Short-container-title:Biochemistry

Author:

Bell Rosie¹,Thrush Rebecca J.¹,Castellana-Cruz Marta¹,Oeller Marc¹^ORCID,Staats Roxine¹,Nene Aishwarya¹,Flagmeier Patrick¹,Xu Catherine K.¹,Satapathy Sandeep²,Galvagnion Celine³^ORCID,Wilson Mark R.⁴,Dobson Christopher M.¹,Kumita Janet R.⁵^ORCID,Vendruscolo Michele¹^ORCID

Affiliation:

1. Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, U.K.

2. Department of Cell Biology, Blavantik Institute, Harvard Medical School, Boston, Massachusetts 02115, United States

3. Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen DK-2100, Denmark

4. School of Chemistry and Molecular Bioscience, Molecular Horizons Institute, University of Wollongong, Wollongong, NSW 2522, Australia

5. Department of Pharmacology, University of Cambridge, Cambridge CB2 1PD, U.K.

Funder

Medical Research Council

Publisher

American Chemical Society (ACS)

Subject

Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.biochem.2c00104

Reference75 articles.

1. Parkinson Disease Epidemiology, Pathology, Genetics, and Pathophysiology

2. Global, regional, and national burden of Parkinson's disease, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

3. An updated review of Parkinson's disease genetics and clinicopathological correlations

4. The genetics of Parkinson disease

5. α-Synuclein in Lewy bodies

Cited by 24 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Residues 2 to 7 of α-synuclein regulate amyloid formation via lipid-dependent and lipid-independent pathways;Proceedings of the National Academy of Sciences;2024-08-12

2. Alpha Synuclein Toxicity and Non-Motor Parkinson’s;Cells;2024-07-27

3. The role of Nα‐terminal acetylation in protein conformation;The FEBS Journal;2024-06-23

4. The N-terminal Region of α-Synuclein Controls Amyloid Nucleation at the Condensate Interface;2024-06-06

5. Residues 2-7 of α-synuclein regulate amyloid formation via lipid-dependent and -independent pathways;2024-05-24