Dissecting the Kinetic Mechanism of Human Lysine Methyltransferase 2D and Its Interactions with the WRAD2 Complex-Reference-Cited by-同舟云学术

Dissecting the Kinetic Mechanism of Human Lysine Methyltransferase 2D and Its Interactions with the WRAD2 Complex

Published:2022-09-07 Issue:18 Volume:61 Page:1974-1987
ISSN:0006-2960
Container-title:Biochemistry
language:en
Short-container-title:Biochemistry

Author:

Edwardes Lucy V.¹,Caswell Sarah J.¹,Giurrandino Mariacarmela¹,Zhai Xiang²,Gohlke Andrea³,Kostomiris Demetrios H.²,Pollard Hannah K.¹,Pflug Alexander³^ORCID,Hamm Gregory R.⁴,Jervis Kate V.¹^ORCID,Clarkson Paul N.¹,Syson Karl¹^ORCID

Affiliation:

1. Discovery Biology, Discovery Sciences, BioPharmaceuticals, R&D, AstraZeneca, Cambridge CB4 0WG, U.K.

2. Mechanistic and Structural Biology, Discovery Sciences, BioPharmaceuticals, R&D, AstraZeneca, Boston, Massachusetts 02210, United States

3. Mechanistic and Structural Biology, Discovery Sciences, BioPharmaceuticals, R&D, AstraZeneca, Cambridge CB4 0WG, U.K.

4. Imaging and Data Analytics, Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge CB4 0WG, U.K.

Funder

AstraZeneca

Publisher

American Chemical Society (ACS)

Subject

Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.biochem.2c00385

Reference54 articles.

1. Modes of Interaction of KMT2 Histone H3 Lysine 4 Methyltransferase/COMPASS Complexes with Chromatin

2. Writing, erasing and reading histone lysine methylations

3. Chromatin Modifications and Their Function

4. Cellular Memory and the Histone Code

5. Beyond histones - the expanding roles of protein lysine methylation

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