Bromodomain Interactions with Acetylated Histone 4 Peptides in the BRD4 Tandem Domain: Effects on Domain Dynamics and Internal Flexibility-Reference-Cited by-同舟云学术

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Bromodomain Interactions with Acetylated Histone 4 Peptides in the BRD4 Tandem Domain: Effects on Domain Dynamics and Internal Flexibility

Published:2022-10-10 Issue:21 Volume:61 Page:2303-2318
ISSN:0006-2960
Container-title:Biochemistry
language:en
Short-container-title:Biochemistry

Author:

Wernersson Sven¹,Bobby Romel²,Flavell Liz³,Milbradt Alexander G.²,Holdgate Geoffrey A.²,Embrey Kevin J.²,Akke Mikael¹^ORCID

Affiliation:

1. Biophysical Chemistry, Center for Molecular Protein Science, Department of Chemistry, Lund University, SE-221 00Lund, Sweden

2. Mechanistic and Structural Biology, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, CambridgeCB4 0WG, U.K.

3. Discovery Biology, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge Science Park, CambridgeCB4 0WG, U.K.

Funder

Vetenskapsr?det

Publisher

American Chemical Society (ACS)

Subject

Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.biochem.2c00226

Reference75 articles.

1. How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers

2. Structure and ligand of a histone acetyltransferase bromodomain

3. The Mechanisms behind the Therapeutic Activity of BET Bromodomain Inhibition

4. Bromodomain biology and drug discovery

5. Suppression of inflammation by a synthetic histone mimic

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1. EP-0108A is a moderation selectively BRD4 BD2 inhibitor with potential AML tumor suppression;Anti-Cancer Drugs;2024-08-28

2. Identification of potent BRD4‐BD1 inhibitors using classical and steered molecular dynamics based free energy analysis;Journal of Cellular Biochemistry;2024-02-05

3. The epigenetic regulatory effect of histone acetylation and deacetylation on skeletal muscle metabolism-a review;Frontiers in Physiology;2023-12-08

4. Nuclear spin relaxation;Nuclear Magnetic Resonance;2023-11-29

5. The BET inhibitors JQ1, AZD5153, and I-BET151 co-opt ubiquitin proteasome system components for altering expression of the BRD4 interactome in a human B cell line;2023-11-10

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