Identification of Novel Compounds Inhibiting the Kinase Activity of the CDK5/p25 Complex via Direct Binding to p25-Reference-Cited by-同舟云学术

Identification of Novel Compounds Inhibiting the Kinase Activity of the CDK5/p25 Complex via Direct Binding to p25

Published:2023-04-19 Issue:9 Volume:62 Page:1452-1463
ISSN:0006-2960
Container-title:Biochemistry
language:en
Short-container-title:Biochemistry

Author:

Jabeur Riheb¹²,Corbel Caroline¹,Loyer Pascal³,Le Parc Annabelle⁴,Le Grand Adélaide¹,Comte Arnaud⁵,Bach Stéphane⁶⁷⁸^ORCID,André-Leroux Gwenaëlle⁹,Sire Olivier¹,Ben Mansour Hedi²,Le Tilly Véronique¹^ORCID

Affiliation:

1. IRDL UMR CNRS 6027, Université Bretagne Sud, 56017 Vannes, France

2. Research Unit of Analysis and Process Applied on the Environment─APAE UR17ES32, Higher Institute of Applied Sciences and Technology, Mahdia, University of Monastir, TN5121 Monastir, Tunisia

3. Univ Rennes, INSERM, INRAE, Institut NuMeCan (Nutrition, Metabolisms and Cancer) UMR-A 1341, UMR-S 1241, F-35000 Rennes, France

4. Aspen Pharmacare, 76960 Notre-Dame-de-Bondeville, France

5. Compound Library, ICBMS UMR 5246 CNRS-Université Claude Bernard Lyon 1, Université de Lyon, 69622 Villeurbanne, France

6. Sorbonne Université, CNRS, UMR8227, Integrative Biology of Marine Models Laboratory (LBI2M), Station Biologique de Roscoff, 29680 Roscoff, France

7. Sorbonne Université, CNRS, FR2424, Plateforme de criblage KISSf (Kinase Inhibitor Specialized Screening facility), Station Biologique de Roscoff, 29680 Roscoff, France

8. Centre of Excellence for Pharmaceutical Sciences, North-West University, Private Bag X6001, 2520 Potchefstroom, South Africa

9. Université Paris-Sac, INRAE, MaIAGElay, 78350 Jouy-en-Josas, France

Funder

European Commission

Ligue Contre le Cancer

Publisher

American Chemical Society (ACS)

Subject

Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.biochem.2c00691

Reference60 articles.

1. Structural insights into the functional diversity of the CDK–cyclin family

2. The Roles of Cyclin-Dependent Kinases in Cell-Cycle Progression and Therapeutic Strategies in Human Breast Cancer

3. p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5

4. Neurotoxicity induces cleavage of p35 to p25 by calpain

5. p39 activates cdk5 in neurons, and is associated with the actin cytoskeleton

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