Mechanism of Drug–Drug Interactions Mediated by Human Cytochrome P450 CYP3A4 Monomer-Reference-Cited by-同舟云学术

Mechanism of Drug–Drug Interactions Mediated by Human Cytochrome P450 CYP3A4 Monomer

Published:2015-03-25 Issue:13 Volume:54 Page:2227-2239
ISSN:0006-2960
Container-title:Biochemistry
language:en
Short-container-title:Biochemistry

Author:

Denisov Ilia G.¹,Grinkova Yelena V.¹,Baylon Javier L.¹,Tajkhorshid Emad¹,Sligar Stephen G.¹

Affiliation:

1. Department of Biochemistry, ‡Center for Biophysics and Computational Biology, and §Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States

Funder

National Institute of General Medical Sciences

Publisher

American Chemical Society (ACS)

Subject

Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.biochem.5b00079

Reference86 articles.

1. Critical Review of Preclinical Approaches to Investigate Cytochrome P450–Mediated Therapeutic Protein Drug-Drug Interactions and Recommendations for Best Practices: A White Paper

2. Activation of CYP3A4: Evidence for the Simultaneous Binding of Two Substrates in a Cytochrome P450 Active Site

3. Comparative Analysis of CYP3A Heteroactivation by Steroid Hormones and Flavonoids in Different in Vitro Systems and Potential in Vivo Implications

4. Heterotropic Activation of the Midazolam Hydroxylase Activity of CYP3A by a Positive Allosteric Modulator of mGlu5: In Vitro to In Vivo Translation and Potential Impact on Clinically Relevant Drug-Drug Interactions

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