Human Erythroid 5-Aminolevulinate Synthase Mutations Associated with X-Linked Protoporphyria Disrupt the Conformational Equilibrium and Enhance Product Release

Author:

Fratz Erica J.1,Clayton Jerome1,Hunter Gregory A.1,Ducamp Sarah234,Breydo Leonid1,Uversky Vladimir N.1,Deybach Jean-Charles234,Gouya Laurent234,Puy Hervé234,Ferreira Gloria C.15

Affiliation:

1. Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida 33612, United States

2. Assistance Publique-Hôpitaux de Paris, Centre Français des Porphyries, Hôpital Louis Mourier, 178 rue des Renouillers, 92701 Colombes Cedex, France

3. INSERM U1149, CNRS ERL 8252, Centre de Recherche sur l’inflammation, 16 rue Henri Huchard, 75018, Université Paris Diderot, Site Bichat, 75018 Paris, France

4. Laboratory of Excellence, GR-Ex, Paris, France

5. Department of Chemistry, University of South Florida, Tampa, Florida 33612, United States

Funder

American Heart Association

Agence Nationale de la Recherche

National Institute of General Medical Sciences

Consumers, Health and Food Executive Agency

European Commission

Publisher

American Chemical Society (ACS)

Subject

Biochemistry

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