Cyanovirin-N Binding to <i>N</i>-Acetyl-<scp>d</scp>-glucosamine Requires Carbohydrate-Binding Sites on Two Different Protomers-Reference-Cited by-同舟云学术

Cyanovirin-N Binding to N-Acetyl-d-glucosamine Requires Carbohydrate-Binding Sites on Two Different Protomers

Published:2024-04-09 Issue:10 Volume:63 Page:1270-1277
ISSN:0006-2960
Container-title:Biochemistry
language:en
Short-container-title:Biochemistry

Author:

Maier Irene¹²^ORCID,Kontaxis Georg³,Zimmermann Christian⁴,Steininger Christoph²

Affiliation:

1. Department of Environmental Health Sciences, Fielding School of Public Health, University of California, Los Angeles, 650 Charles E. Young Dr. South, Los Angeles, California 90095, United States

2. Department of Internal Medicine I, Medical University of Vienna, Waehringer Guertel 18-20, Vienna A-1090, Austria

3. Department of Computational and Structural Biology, Max Perutz Laboratories, University of Vienna, Campus Vienna Biocenter 5, Vienna 1030, Austria

4. Institute of Chemical, Environmental and Bioscience Engineering, TU Wien, Gumpendorfer Strasse 1a, Wien 1060, Austria

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.biochem.4c00113

Reference38 articles.

1. Discovery of cyanovirin-N, a novel human immunodeficiency virus-inactivating protein that binds viral surface envelope glycoprotein gp120: potential applications to microbicide development

2. Cyanovirin-N Defines a New Class of Antiviral Agent Targeting N-Linked, High-Mannose Glycans in an Oligosaccharide-Specific Manner

3. Differential Inhibitory Effects of Cyanovirin-N, Griffithsin, and Scytovirin on Entry Mediated by Envelopes of Gammaretroviruses and Deltaretroviruses

4. Multiple Antiviral Activities of Cyanovirin-N: Blocking of Human Immunodeficiency Virus Type 1 gp120 Interaction with CD4 and Coreceptor and Inhibition of Diverse Enveloped Viruses

5. Dissecting carbohydrate–Cyanovirin-N binding by structure-guided mutagenesis: functional implications for viral entry inhibition