Structural and Functional Analyses of Inhibition of Human Dihydroorotate Dehydrogenase by Antiviral Furocoumavirin-Reference-Cited by-同舟云学术

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Structural and Functional Analyses of Inhibition of Human Dihydroorotate Dehydrogenase by Antiviral Furocoumavirin

Published:2024-05-09 Issue:10 Volume:63 Page:1241-1245
ISSN:0006-2960
Container-title:Biochemistry
language:en
Short-container-title:Biochemistry

Author:

Nakahara Miku¹,Watanabe Shogo¹,Sato Michio¹,Okumura Hideo²,Kawatani Makoto³^ORCID,Osada Hiroyuki¹,Hara Kodai¹,Hashimoto Hiroshi¹,Watanabe Kenji¹^ORCID

Affiliation:

1. Department of Pharmaceutical Sciences, University of Shizuoka, Shizuoka 422-8526, Japan

2. SPring-8/JASRI, Hyogo 679-5198, Japan

3. Chemical Resource Development Research Unit, RIKEN Center for Sustainable Resource Science, Wako-shi 351-0198, Japan

Funder

Japan Agency for Medical Research and Development

Japan Society for the Promotion of Science

Secom Science and Technology Foundation

Uehara Memorial Foundation

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.biochem.4c00120

Reference16 articles.

1. Construction of a microbial natural product library for chemical biology studies

2. Identification of a dihydroorotate dehydrogenase inhibitor that inhibits cancer cell growth by proteomic profiling

3. DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer

4. Effect of 6-azauridine on de novo pyrimidine biosynthesis in cultured Ehrlich ascites cells. Orotate inhibition of dihydroorotase and dihydroorotate dehydrogenase.

5. Histidine to alanine mutants of human dihydroorotate dehydrogenase

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