Crystal Structure of the Carbohydrate Recognition Domain of the Human Macrophage Galactose C-Type Lectin Bound to GalNAc and the Tumor-Associated Tn Antigen-Reference-Cited by-同舟云学术

Crystal Structure of the Carbohydrate Recognition Domain of the Human Macrophage Galactose C-Type Lectin Bound to GalNAc and the Tumor-Associated Tn Antigen

Published:2021-03-16 Issue:17 Volume:60 Page:1327-1336
ISSN:0006-2960
Container-title:Biochemistry
language:en
Short-container-title:Biochemistry

Author:

Gabba Adele¹²^ORCID,Bogucka Agnieszka¹²^ORCID,Luz John G.¹^ORCID,Diniz Ana³^ORCID,Coelho Helena³^ORCID,Corzana Francisco⁴^ORCID,Cañada Francisco Javier⁵⁶^ORCID,Marcelo Filipa³^ORCID,Murphy Paul V.²^ORCID,Birrane Gabriel¹^ORCID

Affiliation:

1. Division of Experimental Medicine, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, United States

2. School of Chemistry, National University of Ireland Galway, Galway H91 TK33, Ireland

3. UCIBIO, REQUIMTE, Departamento de Química, Faculdade de Ciências e Tecnologia, Universidade de Nova de Lisboa, 2829-516 Caparica, Portugal

4. Departamento de Química, Centro de Investigación en Síntesis Química Universidad de La Rioja, 26006 Logroño, Spain

5. Centro de Investigaciones Biológicas Margarita Salas, CSIC, Ramiro de Maeztu 9, 28040 Madrid, Spain

6. CIBER de Enfermedades Respiratorias (CIBERES), Avda Monforte de Lemos 3-5, 28029 Madrid, Spain

Funder

Science Foundation Ireland

Irish Research Council

Instituto de Salud Carlos III

Funda??o para a Ci?ncia e a Tecnologia

Agencia Estatal de Investigaci?n, Ministerio de Ciencia, Innovaci?n y Universidades

Gabrielle's Angel Foundation for Cancer Research

Publisher

American Chemical Society (ACS)

Subject

Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.biochem.1c00009

Reference50 articles.

1. Novel insights into the immunomodulatory role of the dendritic cell and macrophage-expressed C-type lectin MGL

2. Sweet preferences of MGL: carbohydrate specificity and function

3. The C-type lectin MGL expressed by dendritic cells detects glycan changes on MUC1 in colon carcinoma

4. Targeting self- and foreign antigens to dendritic cells via DC-ASGPR generates IL-10–producing suppressive CD4+ T cells

5. MGL signaling augments TLR2-mediated responses for enhanced IL-10 and TNF-α secretion

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