Molecular Features of CA-074 pH-Dependent Inhibition of Cathepsin B-Reference-Cited by-同舟云学术

Molecular Features of CA-074 pH-Dependent Inhibition of Cathepsin B

Published:2022-02-04 Issue:4 Volume:61 Page:228-238
ISSN:0006-2960
Container-title:Biochemistry
language:en
Short-container-title:Biochemistry

Author:

Yoon Michael C.¹²^ORCID,Christy Mitchell P.³,Phan Von V.¹²,Gerwick William H.³^ORCID,Hook Gregory⁴,O’Donoghue Anthony J.¹^ORCID,Hook Vivian¹⁵^ORCID

Affiliation:

1. Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California 92093-0021, United States

2. Biomedical Sciences Graduate Program, University of California, San Diego, La Jolla, California 92093-0021, United States

3. Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093-0021, United States

4. American Life Sciences Pharmaceuticals, Inc., La Jolla, California 92037-5149, United States

5. Department of Neurosciences and Department of Pharmacology, School of Medicine, University of California, San Diego, La Jolla, California 92093-0021, United States

Funder

National Institute of Neurological Disorders and Stroke

Publisher

American Chemical Society (ACS)

Subject

Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.biochem.1c00684

Reference59 articles.

1. Cysteine cathepsins: From structure, function and regulation to new frontiers

2. Specialized roles for cysteine cathepsins in health and disease

3. Cathepsin B in neurodegeneration of Alzheimer's disease, traumatic brain injury, and related brain disorders

4. Cathepsin B plays a critical role in inducing Alzheimer’s disease-like phenotypes following chronic systemic exposure to lipopolysaccharide from Porphyromonas gingivalis in mice

5. Deletion of the Cathepsin B Gene Improves Memory Deficits in a Transgenic Alzheimer's Disease Mouse Model Expressing AβPP Containing the Wild-Type β-Secretase Site Sequence

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