Probing the Conformational Dynamics of Affinity-Enhanced T Cell Receptor Variants upon Binding the Peptide-Bound Major Histocompatibility Complex by Hydrogen/Deuterium Exchange Mass Spectrometry-Reference-Cited by-同舟云学术

Probing the Conformational Dynamics of Affinity-Enhanced T Cell Receptor Variants upon Binding the Peptide-Bound Major Histocompatibility Complex by Hydrogen/Deuterium Exchange Mass Spectrometry

Published:2021-03-09 Issue:11 Volume:60 Page:859-872
ISSN:0006-2960
Container-title:Biochemistry
language:en
Short-container-title:Biochemistry

Author:

Merkle Patrick S.¹,Trabjerg Esben¹,Hongjian Song¹,Ferber Mathias²,Cuendet Michel A.²³,Jørgensen Thomas J. D.⁴^ORCID,Luescher Immanuel⁵,Irving Melita²⁵,Zoete Vincent²^ORCID,Michielin Olivier²,Rand Kasper D.¹^ORCID

Affiliation:

1. Department of Pharmacy, University of Copenhagen, 2100 Copenhagen, Denmark

2. Swiss Institute of Bioinformatics, Bâtiment Génopode, UNIL Sorge, 1015 Lausanne, Switzerland

3. Weill Cornell Medical College, 1300 York Avenue, New York, New York 10065, United States

4. Department of Biochemistry and Molecular Biology, University of Southern Denmark, 5230 Odense, Denmark

5. Ludwig Branch for Cancer Research of the University of Lausanne, 8001 Zurich, Switzerland

Funder

Det Frie Forskningsr?d

Novo Nordisk Fonden

Human Frontiers Science Programme

The Marie Curie Actions Programme of the E.U.

Publisher

American Chemical Society (ACS)

Subject

Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.biochem.1c00035

Reference83 articles.

1. Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system

2. The epitopes of influenza nucleoprotein recognized by cytotoxic T lymphocytes can be defined with short synthetic peptides

3. HOW TCRS BIND MHCS, PEPTIDES, AND CORECEPTORS

4. Crystal Structure of the β Chain of a T Cell Antigen Receptor

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